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Bills vs 49ers NFL Week 13 betting odds, tips & predictions

Bills vs 49ers NFL betting picks

Buffalo Bills vs San Francisco 49ers

Latest Odds & Game Info

NFL moneyline odds Bills -104.17 at Bovada | 49ers -117.65 at Bovada
When Monday, December 7, 2020 – 6:15pm MST
Where State Farm Stadium – Glendale, Arizona
Watch Live ESPN (US & AU), Sky Sports (UK), NFL Game Pass

Buffalo Bills vs San Francisco 49ers betting preview

When the county of Santa Clara banned contact sports due to the rise of COVID-19 cases in California, the San Francisco 49ers’ season was left in limbo. Fortunately for the 49ers, they were able to work out a deal with the city of Glendale to play their remaining home games in Arizona. The 49ers will host the Buffalo Bills this Monday night at the State Farm Stadium, and we’ve taken a look at the latest odds and bets bets on offer at our top-rated online sportsbooks.

The San Francisco 49ers have been ravaged by injuries on both sides of the ball this season. While their offense has gotten some key players back in recent weeks in starting running back Raheem Mostert and top wide receiver Deebo Samuel, the 49ers are still missing starting quarterback Nick Mullens and perennial all-star tight end George Kittle. Key injuries on defense include Nick Bosa, Solomon Thomas, and Richard Sherman. Despite all of these injuries, San Francisco managed to snap a three-game losing streak last Sunday with a 23-20 win over the Los Angeles Rams to improve to 5-6 straight up and against the spread on the season.

The Buffalo Bills also picked up a victory last Sunday, improving to 4-1 and 3-2 ATS over their last five games with a 27-17 win over the Los Angeles Chargers. The Bills are now 8-3 and 6-5 ATS and enter this weekend in first place in the AFC East. Buffalo hasn’t won its division since 1995, which was also the last season that the Bills won a playoff game. This looks like the team that could snap those long franchise droughts.

Interestingly, the Bills opened as 2.5-point road favorites in this one but have been bet down to 1-point underdogs in the week leading up to the game. This could be due to the fact that the 49ers have an excellent passing defense, which ranks fourth in the NFL and allows only 206.5 passing yards per game, and the Bills are fairly one-dimensional in their offensive attack, relying heavily on the passing game.

Still, this feels like a bit of an overreaction to San Francisco’s win over the Rams. The 49ers went 0-3 straight up and ATS over their previous three games and gave up 32.7 points per game against three pass-heavy teams. Buffalo is the healthier and more well-rounded team, so we say go against the NFL betting public and take the Bills in this one.

Best bets for Bills vs 49ers

Buffalo Bills +1


Under 47 total points

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