New York Giants @ San Francisco 49ers NFL Thursday betting picks

The NFL’s Thursday Night Football returns with a Week 3 showcase between the 2-0 San Francisco 49ers and the 1-1 New York Giants. While both of these teams were playoff squads last year, San Francisco are expected to dominate this game. Here are our top NFL betting picks for Thursday, September 21.

Giants @ 49ers spread pick: NY Giants +10.5

The Giants may not be expected to win this game, but we think they can keep it close. While the Niners are off to a great start and the Giants have stumbled out of the gates, New York haven’t played to their potential. Also, even though they will be without their best offensive weapon, Saquon Barkley, they still have enough talent to keep it close. Thursday games are typically pretty sloppy, so we will take the heavy underdogs and hope it doesn’t get away from them.

Giants anytime TD pick: Matt Breida

Matt Breida is the backup running back for the New York Giants, but with the injury to starter Saquon Barkley, he should get a lot of work. While the Niners have a great defense, the value on this anytime touchdown bet is too good to pass up. The Giants will struggle to run the ball all night, but Breida is also a talented pass-catcher, and he can beat the San Francisco defense in more ways than one.

49ers anytime TD pick: George Kittle

George Kittle is one of the most talented tight ends in football, and while he is yet to score for the 49ers this season, he put up 11 touchdowns last year. Kittle poses a unique matchup problem for the Giants, as his combination of size and speed is tough for anyone to deal with. New York have been average against opposing tight ends through two weeks, but Kittle is on a different level, and we like him to score in this Thursday Night battle.

More sports betting picks