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NFL Thanksgiving & Black Friday betting preview, top picks & odds

NFL Week 12 betting preview

The NFL returns in Week 12 with its annual slate of three games for Thanksgiving, and this year the league has added a Black Friday game to the schedule. With the Detroit Lions, Miami Dolphins, and San Francisco 49ers in action, each matchup promises to be highly entertaining. Here are our best NFL betting picks for each game.

Green Bay Packers @ Detroit Lions

Thursday, November 23 – 12:30pm EST – Ford Field

Although the Packers have historically dominated the Lions in this longstanding divisional rivalry, this time it might be different. While Detroit are favored to go 9-2, they’ve only covered the spread once in their last four games, mainly due to defensive struggles. Green Bay’s offense may not be the most potent, but they should manage to score and keep the game within the spread.

Green Bay Packers +7.5


Washington Commanders @ Dallas Cowboys

Thursday, November 23 – 4:30pm EST – AT&T Stadium

Brandin Cooks, a veteran wide receiver in his first year with Dallas, has gradually carved out a valuable role after a slow start. With three touchdowns in his last five games, he has become a trusted weapon for Cowboys quarterback Dak Prescott. Facing the league’s worst passing defense, Dallas should dominate. At +175 with top NFL betting sites, Cooks holds favorable odds to contribute a touchdown.

Brandin Cooks anytime touchdown


San Francisco 49ers @ Seattle Seahawks

Thursday, November 23 – 8:20pm EST – Lumen Field

After overcoming a three-game losing streak, the San Francisco 49ers have been dominant in their recent two wins. Despite Seattle’s inconsistency, they are expected to perform well in this home game. The Niners’ strong defense can be exploited through the air, and with Seattle’s solid passing attack and a 4-1 home record, they’re poised to cover the spread.

Seattle Seahawks +6.5


Miami Dolphins @ New York Jets

Friday, November 24 – 3pm EST – Metlife Stadium

While the Dolphins should secure the win in the NFL’s first-ever Black Friday game, their leaky defense might give the Jets’ struggling offense opportunities to score. Additionally, the Jets boast a solid defense that could limit Miami’s offensive prowess. As this is a must-win home game for the Jets, they hold all the value. Expect an ugly affair that could be closer than the NFL betting odds suggest.

New York Jets +10


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