Serie A Matchday 2 preview & best bets | August 29-31, 2025

Serie A 2025/26 rolls into Matchday 2 this weekend, with Italy’s top flight serving a full slate across Saturday and Sunday.

Bologna will host promoted Como to kick things off, while Inter return to San Siro against Udinese. Juventus head to Genoa, Milan visit Lecce, and Napoli welcome Cagliari in front of a fired-up Maradona crowd.

Check out BettingPlanet.com’s top picks for every game in Serie A Matchday 2, with odds from the world’s best online bookmakers.

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Cremonese vs Sassuolo

Saturday, August 29 – 6:30pm CEST – Stadio Giovanni Zini

Cremonese arrive buzzing after a 2–1 shock at Milan; Sassuolo, meanwhile, couldn’t land a blow in a 2–0 loss to champions Napoli. Promoted or not, Cremonese showed they can threaten from set pieces and second-phase attacks, and Sassuolo’s opening day threat was minimal in open play.

Leece vs AC Milan

Friday, August 29 – 8:45pm CEST – Stadio Ettore Giardiniero

Lecce ground out a 0–0 at Genoa in their opening fixture, but Milan’s 2–1 home loss to Cremonese will sharpen focus. Expect Milan to control field position and protect against counters, with a cleaner defensive line after their opening-round lapse.

Bologna vs Como

Saturday, August 30 – 6:30pm CEST – Stadio Renato Dall’Ara

Bologna were edged out 1–0 at Roma on opening weekend, while newly promoted Como stunned Lazio 2–0 thanks to a clean sheet and quick transitions. Based off the opening weekend, expect an arm-wrestle at the Dall’Ara. With Bologna still finding fluency and Como organized, the draw is the value play with top soccer betting sites.

Parma vs Atalanta

Saturday, August 30 – 6:30pm CEST – Ennio Tardini Stadium

Parma’s return to Italy’s top flight started with a 2–0 loss at Juventus. Atalanta were held 1–1 by promoted Pisa, creating plenty of chances but without their ruthless edge. Atalanta’s set-piece craft and rotations should tell over 90 minutes against a promoted team still adjusting to the speed of Serie A.

Napoli vs Cagliari

Saturday, August 30 – 8:45pm CEST – Stadio Diego Armando Maradona

Napoli opened their season with a measured 2–0 victory at Sassuolo, while Cagliari held Fiorentina 1–1. Napoli’s midfield duo of Scott McTominay and Kevin De Bruyne already looks settled, and a home crowd should push the pace after the break.

Pisa vs Roma 

Saturday, August 30 – 8:45pm CEST – Arena Garibaldi Romeo Anconetani

Pisa’s first Serie A game in decades brought a gritty 1–1 at Atalanta, while Roma handled Bologna 1–0. Expect Roma’s size on restarts and calmer final-third choices to control this, with Pisa staying compact until forced to chase a result.

Genoa vs Juventus

Sunday, August 31 – 6:30pm CEST – Luigi Ferraris Stadium

Genoa’s opener finished 0–0 with Lecce, but Juve beat Parma 2–0 despite going down to 10 men. With the wing supply strong and Andrea Cambiaso suspended, expect a solid, no-frills away template under Igor Tudor: protect the box, nick a goal, and manage the clock.

Torino vs Fiorentina

Sunday, August 31 – 6:30pm CEST – Stadio Olimpico Grande Torino

Torino conceded five at Inter to open their Serie A campaign, while Fiorentina drew 1–1 at Cagliari. Toro should react at home, but Fiorentina’s wide supply and late runners usually create a few decent looks.

Inter Milan vs Udinese

Sunday, August 31 – 8:45pm CEST – Stadio Giuseppe Meazza

Inter lit up the San Siro with a 5–0 rout of Torino on Matchday 1, while Udinese drew 1–1 with Verona. Shot volume and territorial dominance should again be blue and black. If the first lands, Cristian Chivu’s men have the ability to stretch the margin as the game wears on.

Lazio vs Hellas Verona

Sunday, August 31 – 8:45pm CEST – Stadio Olimpico

Lazio’s 2–0 defeat at Como set a cautious tone, while Verona opened with a 1–1 draw at Udinese. With one goal between the two teams so far, this does not look like a high-scoring affair.