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MLB American League Betting Preview for Sunday, May 22

MLB best bets

There are 16 MLB games scheduled for Sunday, May 21. There are eight American League games, seven National League games, and an interleague game between Cincinnati and Toronto. Here are the best bets on the games featuring American League teams scheduled for Sunday starting at 11:35 a.m. Eastern. All lines provided by Bovada.

Game 1: Chicago White Sox @ New York Yankees

The White Sox and Yankees play two on Sunday, with the first scheduled for 2:20 p.m. Eastern. Jameson Taillon is expected to start game one for New York, and he’s struggled to a 1.214 OPS allowed to the White Sox.

You might consider placing a player prop bet on Chicago’s Leury Garcia to get at least two hits and more than two total bases. He’s two-for-two with a double and home run against Taillon. Tim Anderson should also be good for a couple of hits. He’s two-for-six against Taillon.

Take Chicago on the moneyline in game one at +160, and consider parlaying that bet with…

Chicago White Sox To Win

+160
@
Bovada

Game 2: Chicago White Sox @ New York Yankees

The Yankees are expected to start Luis Severino in game two of the doubleheader. He’s held Chicago to a .587 OPS in 36 at-bats, despite Jose Abreu going six-for-14 with two doubles against Severino. You might want to bet on Abreu to get a couple of hits or collect two or more total bases.

Starting for the White Sox will be Michael Kopech, who has been stellar to start the season (1.54 ERA, 0.94 WHIP). The Yankees have posted a .765 OPS against Kopech collectively, and one Yankee has fared particularly well against Kopec. Isaiah Kiner-Falefa is four-of-five against Kopech, so you might want to bet on him to have multiple hits and multiple total bases.

Take the Yankees on the moneyline in game two, and parlay that with the White Sox on the moneyline in game one for +312 odds.

New York Yankees To Win

-169.49
@
Bovada

Detroit Tigers @ Cleveland Guardians

Shane Bieber is on the bump for Cleveland on Sunday, and in 92 at-bats, Tigers batters have just 18 hits and six extra-base hits against Bieber for a .549 OPS. Jonathan Schoop has half of those extra-base hits, with two doubles and a homer. You might want to place a player prop bet on Schoop to collect multiple hits or two or more total bases.

Making just his fourth start for the Tigers, Alex Faedo is coming off his best start of the season at Tampa Bay. He almost completed six innings and allowed just one run. Faedo is a flyball pitcher, however, with 29 of his 48 outs coming on the fly. Expect the veteran Cleveland hitters to turn those fly balls into extra-base hits. Jose Ramirez is particularly hot, collecting a homer and a triple on Friday. Bet on Ramirez to collect two or more hits and total bases, and take the Guardians to win on the moneyline and against the 1.5-run spread.

Cleveland Guardians To Win

-200
@
Bovada

Tampa Bay Rays @ Baltimore Orioles

Baltimore has promoted catching prospect Adley Rutschman, which is exciting for Orioles fans, but more exciting for Orioles fans is facing starter Corey Kluber (.831 OPS allowed vs. Baltimore). Chris Owings is three-for-six with a home run, Cedric Mullins is four-for-10, and Rougned Odor is four-of-11 with two homers against Kluber. A player prop bet on any of these three Orioles to collect two or more total bases is a good bet.

Spenser Watkins will have his struggles starting for Baltimore. Randy Arozarena is four-for-seven against Watkins, and Wander Franco is three-of-nine. Bet on both to collect two or more total bases, but bet on Baltimore to get a boost from Rutschman behind and at the plate. Take the Orioles on the moneyline at +135.

Baltimore Orioles To Win

+135
@
Bovada

There are your best bets for the MLB American League games scheduled for Saturday, May 21 starting at 1:05 p.m. Eastern. Get your bets in before first pitch and please gamble responsibly.
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