EPL Matchweek 4 betting preview & picks | September 13-14

The English Premier League returns following the first international break of the season, with two big derbies headlining the action.

Check out BettingPlanet.com’s free betting preview and predictions for this week’s soccer matches, with odds courtesy of the top sportsbooks in United States.

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Arsenal vs Nottingham Forest

Saturday, September 13 – 12:30pm BST – Emirates Stadium

Arsenal will host Ange Postecoglou’s first match in charge of Nottingham Forest on Saturday afternoon to kick off Matchweek 4 at Emirates Stadium. With aggressive tactics expected from both sides, chances should flow at either end, and three or more goals is very likely.

Bournemouth vs Brighton & Hove Albion

Saturday, September 13 – 3pm BST – Vitality Stadium

Bournemouth have opened the season in strong form with two wins from three, while Brighton & Hove Albion have managed just four points. Antoine Semenyo has two goals and an assist already this season, and with top sportsbooks offering +125 for him to score or assist, the price is hard to pass up.

Crystal Palace vs Sunderland

Saturday, September 13 – 3pm BST – Selhurst Park

Crystal Palace have a great opportunity to strengthen their place in the top six when they host Sunderland at Selhurst Park. The Eagles are one of only three unbeaten teams this season, and after a commanding 3-0 win over Aston Villa before the international break, they should prove too strong for the Black Cats at home.

Everton vs Aston Villa

Saturday, September 13 – 3pm BST – Hill Dickinson Stadium

Everton and Aston Villa meet in one of the weekend’s most intriguing matchups, with the Toffees sitting fifth and Villa in 19th after three games. Everton have scored five times already, while Villa have yet to find the net and will be eager to change that. With an open, free-flowing contest expected, backing both teams to score is the play.

Newcastle United vs Wolverhampton Wanderers

Saturday, September 13 – 3pm BST – St James’ Park

Newcastle United will look for their first win of the 2025/26 EPL campaign when they host Wolverhampton Wanderers on Saturday afternoon. The Magpies have stumbled in two of their first three matches, but Wolves have started just as poorly. Expect Newcastle to break through in a high-scoring contest.

Fulham vs Leeds United

Saturday, September 13 – 3pm BST – Craven Cottage

Fulham can feel a bit unlucky to be sitting 18th after a solid start, taking two points from three matches. Leeds United opened their first season back in the Premier League with a win but have struggled since. At home, Fulham should be too strong.

West Ham United vs Tottenham Hotspur

Saturday, September 13 – 5:30pm BST – London Stadium

West Ham host Tottenham in a derby at London Stadium, fresh off a big 3-0 win over Nottingham Forest. Spurs, meanwhile, are coming off a horror outing against Bournemouth. With 12 goals scored across the last four meetings and both sides favoring attacking play, expect goals at both ends.

Brentford vs Chelsea

Saturday, September 13 – 8pm BST – Gtech Community Stadium

Both Brentford and Chelsea have started the season much as expected, with the Bees struggling and the Blues firing on all cylinders. With just one goal conceded so far, Chelsea are tied with Arsenal and Tottenham for lowest goals against. Expect the Blues to keep a clean sheet and pile on goals at the other end.

Burnley vs Liverpool

Sunday, September 14 – 2pm BST – Turf Moor

Defending champions Liverpool head up the road to Turf Moor as they chase their fourth straight win to open the 2025/26 EPL season. Burnley have yet to show defensive stability, and against Liverpool’s array of attacking weapons, their backline is in for a difficult afternoon.

Manchester City vs Manchester United

Sunday, September 14 – 4:30pm BST – Etihad Stadium

The headline clash of Matchweek 4 is the Manchester derby at Etihad Stadium, with both sides desperate for a win to climb the EPL table. The Sky Blues come in off their second straight defeat, while the Red Devils edged out Burnley 3-2 at home. With both squads showing defensive frailties, this grudge match should deliver plenty of goals.