Get free expert English Premier League previews and betting tips for Matchweek 5, with odds, team form, and soccer insights for all key fixtures.
EPL Matchweek 5 betting predictions & odds – September 20-21
Matchweek 5 of the English Premier League delivers a packed slate headlined by Arsenal vs Manchester City and the always fiery Merseyside Derby between Liverpool and Everton.
Continue reading to find BettingPlanet.com’s free betting preview and tips for the weekend’s key fixtures, with odds courtesy of the top sportsbooks.
Liverpool vs Everton
Saturday, September 20 – 12:30pm BST – Anfield
The Merseyside Derby will kick off Matchweek 5 as Everton travel to Anfield to face longtime rival Liverpool. The Reds are the only team in the EPL to have won all four of their matches, while the Toffees have been a pleasant surprise early on, sitting in sixth place.
Derbies traditionally produce goals, making the over a smart play.
Over 2.5 goals
Brighton & Hove Albion vs Tottenham Hotspur
Saturday, September 20 – 3pm BST – American Express Stadium
Brighton & Hove Albion will host Tottenham Hotspur as they look for their second win of the season after a slow start to the 2025/26 campaign. These sides have produced high-scoring clashes in their last four meetings, with both teams scoring in each and combining for 19 goals.
Both teams to score + Over 3.5 goals
Burnley vs Nottingham Forest
Saturday, September 20 – 3pm BST – Turf Moor
Burnley have shown they won’t be pushovers after earning promotion to the Premier League, despite narrow defeats to Manchester United and Liverpool.
Nottingham Forest, meanwhile, have endured consecutive 3-0 losses to West Ham and Arsenal. Forest must find a way to win this game and spark their climb up the table.
Nottingham Forest to win
West Ham United vs Crystal Palace
Saturday, September 20 – 3pm BST – London Stadium
West Ham United will welcome unbeaten Crystal Palace to the London Stadium as they look to rebound from a 3-0 defeat at the hands of Tottenham. The Eagles earned their third draw of the season last week against Sunderland, despite dominating every aspect of the match.
With a stronger and more consistent defense, Palace look set to claim all three points.
Crystal Palace to win
Wolverhampton Wanderers vs Leeds United
Saturday, September 20 – 3pm BST – Molineux Stadium
Wolverhampton Wanderers and Leeds United have both started slowly, combining for just one win. While Wolves have lost all four, they’ve created chances, and Leeds showed improvement against Newcastle and Fulham.
With top sportsbooks offering +115 for three or more total goals, the over is great value.
Over 2.5 goals
Manchester United vs Chelsea
Saturday, September 20 – 5:30pm BST – Old Trafford
Struggling Manchester United will host undefeated Chelsea on Sunday afternoon, with under-fire manager Ruben Amorim desperate for a win. The Blues were held to a 2-2 draw at Brentford, while United are coming off a 3-0 defeat in the Manchester Derby.
Both teams have scored in four of their last five meetings, with at least three goals in three of the past five.
Both teams to score + Over 2.5 goals
Fulham vs Brentford
Saturday, September 20 – 8pm BST – Craven Cottage
Fulham and Brentford meet for the first time this year, with a back-and-forth clash expected. The sides produced two thrillers last season, with the Cottagers winning 3-2 and 2-1.
Although the Bees enter as underdogs, they’ve scored in each of their four matches, making both teams to score the smart play.
Both teams to score
Bournemouth vs Newcastle United
Sunday, September 21 – 2pm BST – Vitality Stadium
Bournemouth have maintained strong early-season form, winning three of their first four matches after an opening-night loss at Liverpool. Newcastle United, meanwhile, have stumbled, managing just one win and four points so far.
At +145 with top soccer betting sites, Bournemouth offer excellent value.
Bournemouth to win
Sunderland vs Aston Villa
Sunday, September 21 – 2pm BST – Stadium of Light
Sunderland held firm to earn a point against Crystal Palace last week, keeping their place in the top half of the table, while Aston Villa continued to struggle in a scoreless draw at Everton. Villa remain the only Premier League side yet to score through four matches.
Expect a low-scoring contest with limited chances.
Under 2.5 goals
Arsenal vs Manchester City
Sunday, September 21 – 4:30pm BST – Emirates Stadium
Arsenal and Manchester City headline Matchweek 5, with the second-placed Gunners hosting the eighth-placed Sky Blues. Alongside Crystal Palace and Tottenham, Arsenal boast the league’s best defense, conceding just one goal in four games.
With tensions high in this marquee matchup, expect chances to be scarce over the full 90 minutes.
Under 2.5 goals
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