Free Serie A soccer betting tips & preview | September 19-22, 2025

Serie A action continues in Italy with a stacked set of fixtures for Matchday 4 of the 2025/26 season.

Lecce and Cagliari open proceedings on Friday evening, whilst all eyes will be on Lazio and Roma on Sunday afternoon.

Keep reading for BettingPlanet’s free Serie A soccer betting tips for Matchday 4 below.

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Lecce vs Cagliari

Friday, September 19 – 8:45pm CEST – Stadio Ettore Giardiniero

Cagliari arrive with momentum after a controlled 2–0 win over Parma last weekend, banking a clean sheet that’s a useful platform away from home. Lecce, by contrast, were well beaten 4–1 at Atalanta, conceding three after the break as the game stretched—hardly ideal prep before a quick turnaround. Cagliari should be too across the park for the hosts.

Bologna vs Genoa

Saturday, September 20 – 3pm CEST – Stadio Renato Dall’Ara

Riccardo Orsolini is Bologna’s primary penalty taker (19 career conversions) and has started this Serie A campaign in rhythm bagging one goal in two matches with 3.0 shots per 90 and 50% on target. Genoa have struggled in the early rounds (no goals scored, low chance creation), which should tilt territory toward Bologna and the zones where Orsolini cuts in and draws fouls. He’s also scored in this fixture before.

Hellas Verona vs Juventus

Saturday, September 20 – 6pm CEST – Stadio Marcantonio Bentegodi

Kenan Yildiz comes in off a confidence-boosting strike in Juventus’ 4–3 Derby d’Italia win over Inter, where his movement between the lines and decisive left-foot finish stood out. Verona’s early numbers invite chances: they’ve conceded 1.67 goals per game across the opening rounds, with opponents scoring first in 67% of matches—game states that suit a forward who attacks space and cutbacks.

Udinese vs AC Milan

Saturday, September 20 – 8:45pm CEST – Bluenergy Stadium

AC Milan have started 2–1–0 across the first three league games with a 1–0 win over Bologna on September 14 that underlined their control in tight matches. Udinese, meanwhile, have taken just one point from their opening two fixtures (1–1, 1–2), suggesting they’re still searching for rhythm. Even with keeper Mike Maignan out, Milan’s structure looked solid in that Bologna win, keeping the edge for an away victory.

Lazio vs Roma

Sunday, September 21– 12:30pm CEST – Stadio Olimpico

Roma are a sensible play in the Derby della Capitale. They opened the league with a controlled 1–0 over Bologna and, Torino’s 0–1 smash-and-grab aside, had gone nine months unbeaten at the Olimpico—evidence of a sturdy baseline under Gian Piero Gasperini. Lazio are still settling after Maurizio Sarri’s June return and have swung from a 0–2 defeat at newly promoted Como to a 4–0 home romp against Verona—volatile signals ahead of a high-stress derby.

Roma’s defensive structure and set-piece threat make them the side to edge a tight one.

Cremonese vs Parma

Sunday, September 21 – 3pm CEST – Stadio Giovanni Zini

Cremonese opened with statement wins—2–1 at Milan and 3–2 against Sassuolo—before a professional 0–0 at Verona, so confidence is high heading into Sunday. Parma are winless and goal-shy through three: 0–2 at Juventus, 1–1 against Atalanta, 0–2 at Cagliari. Cremonese should be too good for their rivals.

Torino vs Atalanta

Sunday, September 21 – 3pm CEST – Stadio Olimpico Grande Torino

Atalanta just thumped Lecce 4–1, with Charles De Ketelaere producing a brace plus a slick assist for Nicola Zalewski; the performance came with volume too (19 shots, 8 on target). Torino did stun Roma 1–0 last weekend, but that was their first league win of the season, and they created little after going ahead. If Atalanta score first, it is hard to see how Torino peg them back

Fiorentina vs Como

Sunday, September 21 – 6pm CEST – Stadio Artemio Franchi

Como’s first three Serie A games have all gone low: 2–0 against Lazio, 0–1 at Bologna and 1–1 against Genoa, pointing to a compact, risk-averse approach. Fiorentina are winless after three and come off a 1–3 defeat to Napoli, so a more controlled game state is likely as they try to steady.

Inter vs Sassuolo

Sunday, September 21 – 8:45pm CEST – Stadio Giuseppe Meazza

Inter just controlled Ajax 2–0 away in the UCL opener, with Marcus Thuram scoring twice from Hakan Çalhanoğlu corners—evidence of repeatable set-piece threat and chance volume that can snowball at home. Sassuolo are newly back in Serie A and look vulnerable early: two defeats from two with 2.5 goals conceded per game. With Inter’s firepower and set pieces tilting the game in their favour convincingly, a three-goal margin (or more) lands the ticket.

Napoli vs Pisa

Monday, September 22 – 8:45pm CEST – Stadio Diego Armando Maradona

Napoli have started perfectly: 2–0 at Sassuolo, 1–0 at home to Cagliari, and a controlled 3–1 win at Fiorentina last weekend. Pisa are newly promoted after 34 years away and showed teething issues with a 0–1 home defeat to Udinese in Matchday 3—now they step up into Naples on Monday night. With Napoli’s talent edge, set-piece quality and Antonio Conte’s structure, Napoli should prove too strong for the visitors.