Sweet 16 action continues Friday with two elite matchups. Get our top NCAA betting picks for Michigan State v Ole Miss and Houston v Purdue.
Sweet 16 Friday: Best NCAA Tournament betting tips & odds
Sweet 16 action rolls into Friday with two high-stakes matchups that could go down to the wire. Friday’s schedule features elite defenses, veteran guards, and a potential Final Four preview as No.1 seed Houston take on a red-hot Purdue team.
Let’s dive into the best NCAA Tournament bets for Friday, March 28.
Sweet 16 betting picks
Michigan State v Ole Miss
Michigan State’s defense has been the story of their tournament run, holding opponents to under 65 points in four of their last five games. Ole Miss bring a high-octane offense but have struggled against elite defensive units all season. Look for Tom Izzo’s Spartans to control the tempo and grind out another statement win.
MI State -3.5
Houston v Purdue
This could be the game of the tournament. Houston’s smothering defense faces off against Purdue’s Zach Edey-led interior game. While the Cougars will look to pressure the ball and force turnovers, Purdue’s size advantage is hard to ignore. Expect a slower pace and a tight contest that stays within reach all night.
Under 131.5 points
March Madness Parlay of the Day
The Sweet 16 wraps up with two massive matchups, and we’re backing gritty defense and seasoned coaching to get the job done. Here’s the best two-leg multi for Friday.
Michigan State -3.5
Houston v Purdue under 131.5
TOTAL RETURN: $3.45
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