NFL Week 5 betting preview, predictions & parlay picks

The first October slate of the NFL season brings London action, divisional duels, and two undefeated heavyweights trying to stay perfect. The Eagles host the Broncos, the Bills welcome the Patriots, and Monday Night Football closes with Patrick Mahomes and the Chiefs on the road against Jacksonville.

We’ve broken down every matchup with one confident betting pick — from spreads and totals to touchdown scorers and player props — and finished with a multi-leg parlay to place with the top online betting sites.

• 

  Fast Payouts

San Francisco 49ers at Los Angeles Rams

Thursday, October 2 – 8:15pm ET – SoFi Stadium, Inglewood, CA

The 49ers enter banged up and facing a short turnaround, while the Rams’ defensive front has been generating consistent pressure. San Francisco’s offense has struggled to sustain drives when playing from behind, and that could be an issue if the Rams jump out early. Indoors under the lights, this projects as more of a defensive tilt than the market suggests.

Minnesota Vikings vs Cleveland Browns

Sunday, October 5 – 9:30am ET – Tottenham Hotspur Stadium, London, UK

The Vikings head to London looking to capitalize on Cleveland’s lack of offensive rhythm. The Browns have cycled through quarterbacks and struggled to protect the passer, while Minnesota’s pass rush has shown flashes in recent weeks. With both defenses capable of limiting explosive plays, the steadier side is the Vikings, who should cover this short number overseas.

Houston Texans at Baltimore Ravens

Sunday, October 5 – 1:00pm ET – M&T Bank Stadium, Baltimore, MD

Baltimore have been hit hard by injuries, but they’re still in position to rebound at home. The Texans have lacked punch offensively, especially in the red zone, where their drives often stall. Even without Lamar Jackson fully fit, the Ravens’ defense and home advantage give them a real edge in a matchup they can’t afford to drop.

New York Giants at New Orleans Saints

Sunday, October 5 – 1:00pm ET – Caesars Superdome, New Orleans, LA

The Giants have new life with Jaxson Dart under center, and they’ll need their young weapons to step up again. New Orleans are winless and have been battered at the line of scrimmage, opening up chances for skill players to break through. Chris Olave remains their most dangerous weapon, and in front of home fans, he’s primed to find the end zone at value odds.

Miami Dolphins at Carolina Panthers

Sunday, October 5 – 1:00pm ET – Bank of America Stadium, Charlotte, NC

Miami finally grabbed a win last week, but losing Tyreek Hill leaves a massive hole in their offense. That puts more pressure on Jaylen Waddle, who has already shown his ability to stretch defenses vertically. Against a Carolina unit that has been inconsistent week to week, Waddle should get increased red-zone looks and deliver as a scoring option.

Las Vegas Raiders at Indianapolis Colts

Sunday, October 5 – 1:00pm ET – Lucas Oil Stadium, Indianapolis, IN

Both sides have dangerous running games and quarterbacks capable of creating chunk plays, which points to a higher-scoring contest. The Colts’ turnover issues also open the door for the Raiders to cash in on short fields. With both defenses prone to lapses, this total looks beatable in what could turn into a shootout.

Denver Broncos at Philadelphia Eagles

Sunday, October 5 – 1:00pm ET – Lincoln Financial Field, Philadelphia, PA

The Eagles remain unbeaten thanks to clutch play in key moments, even when the stat sheet hasn’t been pretty. Denver’s defense is tough, but traveling east for an early kickoff is never ideal, especially against a physical Philadelphia front. Expect another close game, but the Eagles’ late-game polish should see them win by a manageable margin.

Dallas Cowboys at New York Jets

Sunday, October 5 – 1:00pm ET – MetLife Stadium, East Rutherford, NJ

Dallas come off an explosive tie with the Packers that showcased their ability to put points on the board. The Jets’ defense has leaked big plays, and their offense hasn’t been efficient enough to keep pace in shootouts. With Javonte Williams likely to feature heavily, the Cowboys look well placed to cover a short spread on the road.

Tennessee Titans at Arizona Cardinals

Sunday, October 5 – 4:05pm ET – State Farm Stadium, Glendale, AZ

The Cardinals have been relying on Trey McBride as a key red-zone target, and that trend should continue against Tennessee. The Titans’ defense has allowed tight ends to produce, and Kyler Murray’s chemistry with McBride continues to grow. With Arizona expected to move the ball, McBride remains strong value to cross the line.

Tampa Bay Buccaneers at Seattle Seahawks

Sunday, October 5 – 4:05pm ET – Lumen Field, Seattle, WA

Seattle’s pass defense has been among the league’s best, but Tampa Bay’s receiving corps still creates mismatches. Rookie Emeka Egbuka has shown flashes and is being used in high-leverage scoring situations. In what could be a tight contest, he offers real upside as a longshot anytime scorer.

Washington Commanders at Los Angeles Chargers

Sunday, October 5 – 4:25pm ET – SoFi Stadium, Inglewood, CA

The Chargers are dealing with offensive line issues, but Justin Herbert still has the weapons to get the job done at home. Washington’s defense can be opportunistic, yet their inconsistency has left them vulnerable to efficient quarterbacks. If the Chargers control tempo early, they’re well set to cover this modest spread.

Detroit Lions at Cincinnati Bengals

Sunday, October 5 – 4:25pm ET – Paycor Stadium, Cincinnati, OH

The Lions are firing on all cylinders, with Jared Goff leading an attack that has been both balanced and explosive. Cincinnati’s offense, meanwhile, continues to stall without consistent quarterback play. If Detroit build another fast start, their ability to pile on points should push this toward a two-touchdown margin.

New England Patriots at Buffalo Bills

Sunday, October 5 – 8:20pm ET – Highmark Stadium, Orchard Park, NY

Josh Allen has tormented New England in recent meetings, and this matchup again sets up for him to use his legs. The Patriots’ defense has given up yards to mobile quarterbacks, particularly in late-game situations. In a primetime environment, expect Allen to take matters into his own hands and hit the rushing mark.

Kansas City Chiefs at Jacksonville Jaguars

Monday, October 6 – 8:15pm ET – EverBank Stadium, Jacksonville, FL

Jacksonville have been one of the early surprises of the season, with Travis Etienne giving them balance on the ground. Kansas City remain dangerous, but their offense is still trying to find consistency outside of Mahomes’ brilliance. At home with momentum, the Jaguars are strong value to land another statement win.

NFL Week 5 parlay picks

• Under 45.5 (49ers v Rams)
• Vikings -3.5
• Ravens to win
• Chris Olave anytime TD
• Jaylen Waddle anytime TD
• Over 48.5 (Raiders v Colts)
• Eagles by 1–13 pts
• Cowboys -2.5
• Trey McBride anytime TD
• Emeka Egbuka anytime TD
• Chargers -2.5
• Lions 14+
• Josh Allen 40+ rushing yards
• Jaguars to win