San Marino MotoGP predictions & betting tips | September 11-14

The San Marino Grand Prix returns to the iconic Misano World Circuit Marco Simoncelli from September 11–14, promising another chapter in what’s been a thrilling MotoGP season.

Set along Italy’s Adriatic coast, Misano offers a mix of flowing corners and tight technical sectors that demand precision and consistency — the kind of layout that has historically rewarded well-balanced bikes and in-form riders.

Marc Márquez remains the clear championship frontrunner and comes into the weekend as the dominant favorite at -227.27 with top sportsbooks. The Ducati ace has been near-unbeatable of late, and Misano’s flowing configuration only enhances his chances of pulling further ahead in the title chase.

Standing firmly in his way is Álex Márquez, who has become his brother’s chief rival in the title race. The younger Márquez has shown both one-lap pace and the ability to go deep on race day. With the Gresini Ducati underneath him and a proven record at this circuit, he looms as the most likely to break Marc’s run of dominance.

Further down the market, the likes of Enea Bastianini and Johann Zarco offer some interesting MotoGP betting alternatives for punters chasing value in the 2025 San Marino Grand Prix.

2025 San Marino MotoGP race winner odds

• Marc Márquez (ESP-Ducati) – -227.27
• Álex Márquez (ESP-Ducati) – +400
• Marco Bezzecchi (ITA-Aprilia) – +1200
• Francesco Bagnaia (ITA-Ducati) – +1200
• Enea Bastianini (ITA-Ducati) – +1400
• Fabio Quartararo (FRA-Yamaha) – +2000
• Pedro Acosta (ESP-KTM) – +2200
• Fabio Di Giannantonio (ITA-Ducati) – +3300
• Franco Morbidelli (ITA-Ducati) – +4000
• Brad Binder (RSA-KTM) – +5000
• Fermín Aldeguer (ESP-Ducati) – +6000
• Johann Zarco (FRA-Honda) – +6000
• Jorge Martin (ESP-Aprilia) – +6000
• Jack Miller (AUS-Yamaha) – +10000
• Maverick Viñales (ESP-KTM) – +10000
• Luca Marini (ITA-Honda) – +10000
• Raúl Fernández (ESP-Aprilia) – +10000
• Joan Mir (ESP-Honda) – +12500
• Miguel Oliveira (POR-Yamaha) – +12500
• Ai Ogura (JPN-Aprilia) – +12500
• Pol Espargaró (ESP-KTM) – +15000
• Álex Rins (ESP-Yamaha) – +30000
• Aleix Espargaró (ESP-Aprilia) – +50000
• Michele Pirro (ITA-Ducati) – +75000
• Somkiat Chantra (THA-Honda) – +75000
• Augusto Fernández (ESP-KTM) – +75000
• Lorenzo Savadori (ITA-Aprilia) – +100000

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San Marino MotoGP betting predictions

Álex Márquez to win

The younger Marquez in flying form and offers great value at +400 with the top MotoGP betting sites. With growing confidence and full Ducati factory backing, the Misano layout suits his smooth, technical riding style. He’s not a dark horse anymore — he’s a genuine contender.

Enea Bastianini to win

Bastianini is always a threat when the bike clicks, and at a rider-friendly track like Misano, the +1400 price makes him a very playable outsider. He has the aggression and local track knowledge to make it stick if he gets a good launch.

Johann Zarco to win

It’s a long shot, but Zarco’s price at +6000 can’t be ignored. If he finds clean air early or chaos unfolds ahead, the veteran Frenchman has the experience to pounce. This is not your banker bet, but he’s the value bomb of the weekend.

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