US Open men’s quarterfinal picks & odds | September 2-3

We are down to the last eight of the US Open 2025 men’s singles in New York, and there is plenty of top-line talent left in the draw. See our free tennis betting picks and US Open predictions for the quarterfinal matchups at Flushing Meadows on Tuesday and Wednesday.

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  Fast Payouts

Jiri Lehecka v Carlos Alcaraz

Tuesday, September 2 – Arthur Ashe Stadium

Jiri Lehecka beat Carlos Alcaraz in Doha earlier this year, while the Spaniard needed three sets to get past him in the Queen’s final a few months later. Alcaraz is yet to drop a set at the 2025 US Open, yet he didn’t have it all his own way against Arthur Rinderknech in the fourth round. With Lehecka enjoying his best major run since 2023, online bookmakers are giving us decent value for the 23-year-old Czech to win a set at least.

Novak Djokovic v Taylor Fritz

Tuesday, September 2 – Arthur Ashe Stadium

Taylor Fritz is still looking for his first win against Novak Djokovic, who has a 10-0 record against the American. After each dropped a couple of sets early in the draw, both players seemed to find their groove in the fourth round. Fritz’s elite serving should ensure the set scores are fairly tight, but it’s hard to bet against Djokovic getting the job done.

Felix Auger-Aliassime v Alex de Minaur

Wednesday, September 3 – Arthur Ashe Stadium

Alex de Minaur is desperate to clear the quarterfinal hurdle at last, while Felix Auger-Aliassime hasn’t gone this far at the majors since 2022. De Minaur won their last matchup, but Auger-Aliassime made a statement against Alexander Zverev and followed up with a strong straight-sets win over Andrey Rublev. At underdog odds with the top tennis betting sites, the Canadian is a solid value pick in what shapes as a tight contest.

Jannik Sinner v Lorenzo Musetti

Wednesday, September 3 – Arthur Ashe Stadium

Lorenzo Musetti has been one of the most impressive performers in the 2025 US Open men’s singles, winning his last three matches in imperious fashion. But Jannik Sinner is a different beast altogether, and it will be interesting to see how these Davis Cup teammates match up in their first ATP Tour meeting since 2023. This is about the point in a tournament when Sinner starts to really fire up, so a three-set win to the Italian superstar is a solid bet.