US Open women’s quarterfinal tips & predictions | September 2-3

The 2025 US Open women’s quarterfinals kick off this Tuesday, and the top tennis bookies are forecasting some lopsided matchups after a few surprises in the preceding rounds. Below are BettingPlanet.com’s US Open predictions for the upcoming clashes in the women’s singles at Flushing Meadows.

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Jessica Pegula v Barbora Krejcikova

Tuesday, September 2 – Arthur Ashe Stadium

Barbora Krejcikova has already knocked out two American hopes, including an almighty rescue job to beat Taylor Townsend in the round of 16. Jessica Pegula has dominated so far, albeit against fairly tame opposition. Krejcikova is a two-time major winner and holds a 2-1 head-to-head advantage over Pegula, but the Czech is coming off a couple of long three-setters and now faces a local hero who rarely loses as favorite at the US Open.

Aryna Sabalenka v Marketa Vondrousova

Tuesday, September 2 – Arthur Ashe Stadium

Tennis betting sites have Aryna Sabalenka pegged as a short-price favorite, yet Marketa Vondrousova has won two of their last three meetings. The Czech underdog has already seen off two top-10 players in the 2025 US Open, so she should be tuned up. Sabalenka is in good touch, but Vondrousova can pinch a set.

Karolina Muchova v Naomi Osaka

Wednesday, September 3 – Arthur Ashe Stadium

Naomi Osaka made a statement with her dominant victory over Coco Gauff in the fourth round, and online bookmakers have brought her into +450 to win a third US Open title. Karolina Muchova has hustled her way through to the last eight, going the distance in every round. Osaka won in three sets when these two met at the 2025 Australian Open, and there is good value on offer for a repeat result.

Amanda Anisimova v Iga Swiatek

Wednesday, September 3 – Arthur Ashe Stadium

Amanda Anisimova might have a few scars from the 2025 Wimbledon final, where she failed to win a game as Iga Swiatek cruised to victory. The American has looked good so far, but this is a huge step up in class. Swiatek is aiming for a fourth consecutive major semifinal appearance, and the Polish star should be good enough to cover the game handicap.